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16/01/2017 · Chilblain lupus erythematosus is a rare manifestation of chronic cutaneous lupus erythematosus, first reported by Hutchinson in 1888. According to a review published in 2008, about 70 cases have been reported in the literature, with only few in the adolescent age group. The two forms of CHLE are described - familial and sporadic.
Chilblain lupus, known also as perniotic lupus, is a persistent form of discoid lupus erythematosus that involves the fingertips, nose, face, ears, hands, calves, and heels. It is thought to result from injury to small blood vessels secondary to exposure to cold.

Pernio, also referred to as chilblains, is a rare inflammatory condition. Chilblains derives from two Old English words "chill" cold and "blegen" sore. Most commonly, pernio affects acral skin and primarily results as a response to cold, damp conditions. It is typically idiopathic and. 27/01/2017 · Cutaneous lupus erythematosus encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several subtypes, including acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus.

19/11/2019 · Chilblain lupus erythematosus lupus pernio: clinical review of the Mayo Clinic experience and proposal of diagnostic criteria. Su WP1, Perniciaro C, Rogers RS 3rd, White JW Jr. Author information: 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905. Not fun. Chilblains Lupus is a rare symptom of Lupus and most Rheumatologist have never seen a case. Three Rheumatologist saw my feet in person and another three saw the pictures. None of them could identify the sores. Trental and Plaquenil are suggested as treatment for Chilblains Lupus in medical journal articles. Lee-Kirsch MA et al. 2007 Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nat Genet 39: 1065-1067; Lee-Kirsch MA et al. 2006 Familial chilblain lupus, a monogenic form of cutaneous lupus erythematosus, maps to chromosome 3p. Am J Hum Genet 79: 731-737. The clinical features, diagnosis, and management of pernio will be reviewed here. Pernio is distinct from lupus pernio, a form of cutaneous sarcoidosis. Lupus pernio is discussed separately. See "Cutaneous manifestations of sarcoidosis", section on 'Lupus pernio'. EPIDEMIOLOGY. Data on the epidemiology of pernio are limited. 04/05/2018 · Chilblain lupus erythematosus [10, 11]: Violaceous "pernio" plaques appear prominent over dorsal interphalangeal joints, often with positive antinuclear antibody ANA or rheumatoid factor RF. Histologic and immunofluorescent evidence of lupus is present in the skin lesions.

Chilblain lupus is een zeldzame vorm van cutane lupus erythematosus gekenmerkt door pijnlijke blauwrode, paarse of rode papels, plaques of noduli op de acra vingers, tenen, hielen, neus, wangen, oren, knieen, die worden geluxeerd door koude. Chilblain Lupus. definition. Variant of discoid lupus erythematosus characterized by purplish-blue, tender, chilblain-like nodules mainly involving the toes and fingers, but also occurring on the heels, calves, knees, nose and ears.

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